Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions
Identifieur interne : 001195 ( Main/Exploration ); précédent : 001194; suivant : 001196Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions
Auteurs : Nathalie Grova [Luxembourg (pays)] ; Henri Schroeder [France] ; Sophie Farinelle [Luxembourg (pays)] ; Emmanuel Prodhomme [Luxembourg (pays)] ; Anne Valley [France] ; Claude P. Muller [Luxembourg (pays), Allemagne]Source :
- Chemosphere : (Oxford) [ 0045-6535 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Hydrocarbure.
English descriptors
- KwdEn :
Abstract
Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg-1 day-1, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg-1 B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg-1) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions.
Affiliations:
- Allemagne, France, Luxembourg (pays)
- Grand Est, Lorraine (région), Rhénanie-Palatinat
- Trèves (Allemagne), Vandoeuvre les Nancy
- Nancy-Université, Université de Trèves
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Box 1102</s1><s2>1011 Luxembourg</s2><s3>LUX</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1011 Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Schroeder, Henri" sort="Schroeder, Henri" uniqKey="Schroeder H" first="Henri" last="Schroeder">Henri Schroeder</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Neurosciences Comportementales, URAFPA. INRA UC340, Nancy Université, BP 239</s1><s2>54506 Vandoeuvre les Nancy</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandoeuvre les Nancy</settlement></placeName><orgName type="university">Nancy-Université</orgName></affiliation></author><author><name sortKey="Farinelle, Sophie" sort="Farinelle, Sophie" uniqKey="Farinelle S" first="Sophie" last="Farinelle">Sophie Farinelle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Immunology, Laboratoire National de Santé, 20A Rue Auguste Lumière, P.O. Box 1102</s1><s2>1011 Luxembourg</s2><s3>LUX</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1011 Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Prodhomme, Emmanuel" sort="Prodhomme, Emmanuel" uniqKey="Prodhomme E" first="Emmanuel" last="Prodhomme">Emmanuel Prodhomme</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Immunology, Laboratoire National de Santé, 20A Rue Auguste Lumière, P.O. Box 1102</s1><s2>1011 Luxembourg</s2><s3>LUX</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1011 Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Valley, Anne" sort="Valley, Anne" uniqKey="Valley A" first="Anne" last="Valley">Anne Valley</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Neurosciences Comportementales, URAFPA. INRA UC340, Nancy Université, BP 239</s1><s2>54506 Vandoeuvre les Nancy</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandoeuvre les Nancy</settlement></placeName><orgName type="university">Nancy-Université</orgName></affiliation></author><author><name sortKey="Muller, Claude P" sort="Muller, Claude P" uniqKey="Muller C" first="Claude P." last="Muller">Claude P. Muller</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Immunology, Laboratoire National de Santé, 20A Rue Auguste Lumière, P.O. Box 1102</s1><s2>1011 Luxembourg</s2><s3>LUX</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1011 Luxembourg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Immunology, The Graduate School of Psychobiology, University of Trier</s1><s2>54290 Trier</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54290 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author></analytic><series><title level="j" type="main">Chemosphere : (Oxford)</title><title level="j" type="abbreviated">Chemosphere : (Oxf.)</title><idno type="ISSN">0045-6535</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Chemosphere : (Oxford)</title><title level="j" type="abbreviated">Chemosphere : (Oxf.)</title><idno type="ISSN">0045-6535</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult animal</term><term>Anxiety</term><term>Behavior</term><term>Benzopyrene</term><term>Blood</term><term>Encephalon</term><term>Gene</term><term>Glutamate receptor</term><term>Hydrocarbon</term><term>Mechanism of action</term><term>Mouse</term><term>NMDA</term><term>NMDA receptor</term><term>Polycyclic aromatic compound</term><term>Subacute</term><term>Subunit</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Benzo pyrène</term><term>Subaigu</term><term>Benzo[a]pyrène</term><term>Comportement</term><term>Animal adulte</term><term>Souris</term><term>NMDA</term><term>Angoisse anxiété</term><term>Récepteur NMDA</term><term>Gène</term><term>Encéphale</term><term>Récepteur glutamate</term><term>Sousunité</term><term>Sang</term><term>Composé aromatique polycyclique</term><term>Hydrocarbure</term><term>Mécanisme action</term><term>Toxicité</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Hydrocarbure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg<sup>-1</sup> day<sup>-1</sup>, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg<sup>-1</sup> B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg<sup>-1</sup>) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Luxembourg (pays)</li></country><region><li>Grand Est</li><li>Lorraine (région)</li><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li><li>Vandoeuvre les Nancy</li></settlement><orgName><li>Nancy-Université</li><li>Université de Trèves</li></orgName></list><tree><country name="Luxembourg (pays)"><noRegion><name sortKey="Grova, Nathalie" sort="Grova, Nathalie" uniqKey="Grova N" first="Nathalie" last="Grova">Nathalie Grova</name></noRegion><name sortKey="Farinelle, Sophie" sort="Farinelle, Sophie" uniqKey="Farinelle S" first="Sophie" last="Farinelle">Sophie Farinelle</name><name sortKey="Muller, Claude P" sort="Muller, Claude P" uniqKey="Muller C" first="Claude P." last="Muller">Claude P. Muller</name><name sortKey="Prodhomme, Emmanuel" sort="Prodhomme, Emmanuel" uniqKey="Prodhomme E" first="Emmanuel" last="Prodhomme">Emmanuel Prodhomme</name></country><country name="France"><region name="Grand Est"><name sortKey="Schroeder, Henri" sort="Schroeder, Henri" uniqKey="Schroeder H" first="Henri" last="Schroeder">Henri Schroeder</name></region><name sortKey="Valley, Anne" sort="Valley, Anne" uniqKey="Valley A" first="Anne" last="Valley">Anne Valley</name></country><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Muller, Claude P" sort="Muller, Claude P" uniqKey="Muller C" first="Claude P." last="Muller">Claude P. Muller</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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